Temperature elevations due to NIR exposure in the brain tissue
Department of Biomedical Engineering
Master of Science
Pfister, Bryan J.
Al-Smadi, Yahia M.
Near infrared lasers
Low power NIR laser irradiation
Near infrared (N I R) lasers have been used in medical applications both for diagnostic and therapeutic purposes. Temperature elevation profile inside the tissue is a critical factor that needs to be better understood in these applications. The purpose of this study is to determine the temperature distribution due to a low power N I R laser irradiation in living neural tissue. Temperature measurements were made directly using a thermocouple probe inside the rat brain cortex within the sagittal plane. The spatial map indicates that N I R light penetrates more readily in the vertical directions than the spreading in the horizontal axis. The decrease in the vertical direction can be approximated with a single order exponentially decaying function. The results also suggest that the temperature elevation can be kept below 0.5 °C anywhere in the tissue if the incident laser beam power density is less than 27 mW/cm2. These experiments should be repeated in other types of neural tissue such as the white matter of the brain and the spinal cord to obtain more complete results.
njit-etd2012-028 (70 pages ~ 1,086 KB pdf)
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Created June 27, 2012