Cerebral spasticity modeled as disorded equilibrium point control
Department of Biomedical Engineering
Doctor of Philosophy
Foulds, Richard A.
Van Buskirk, William C.
Rosenberg, Michael L.
Merians, Alma S.
Equilibrium point hypothesis (EPH)
Forward kinematic modeling
Spasticity is a highly complex phenomenon, which has not been defined in precise and quantifiable terms. Although the muscle stretch reflex is thought to play an important role in spasticity generation, the pathophysiologic basis of spasticity is not completely understood. A valid measure of spasticity is one that is chosen within the context of a theory describing the physiological mechanisms underlying the control of posture and movement in healthy individuals and possible impairments of these mechanisms leading to motor disorders. This research’s goal was to determine the role of stretch reflex threshold in the regulation of impaired motor control through the exploration of the following research questions:
3. Can the model be robust enough to explain active as well as passive movement?
This research produced a model of passive motion with the ability to produce parameter values that not only differentiate subjects with spasticity from subjects with no clinical signs of spasticity but that can separate subjects based on severity of spastic condition. Research which began as an endeavor to model the passive motion of the pendulum knee test, led to the development of a unifying model of motor control that is robust enough to describe both active and passive movements.
njit-etd2012-002 (146 pages ~ 4,093 KB pdf)
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Created June 27, 2012