| Title: | Ranking single nucleotide polymorphisms with support vector regression in continuous phenotypes |
| Author: | |
| Document Type: | Thesis |
| Department: | Department of Mathematical Sciences |
| Degree: | Master of Science |
| Major: | Computational Biology |
| Advisory Committee: |
Roshan, Usman W.
Wei, Zhi
Dhar, Sunil Kumar
|
| Thesis Date: | 2011, May |
| Keywords: |
Support vector machines
Single nucleotide polymorphisms
Continuous phenotypes
|
| Availability: | Unrestricted |
| Abstract: |
Support vector machines (SVM) have been used to improve the ranking of single nucleotide polymorphisms (SNPs) over traditional chi-square tests in disease case studies [2]. In this investigation, ranking SNPs with support vector regression (SVR) was compared to the Wald test in predicting continuous phenotypes. SVR-ranked SNPs consistently outperformed the Wald test-ranked SNPs to provide a more accurate prediction of the phenotype with fewer SNPs across several methods of prediction. |
| Complete Thesis: | njit-etd2011-082 (59 pages ~ 6,976 KB pdf) |
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Created August 18, 2011
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