NJIT eTD: The New Jersey Institute of Technology's electronic Theses & Dissertations
Title:
Ranking single nucleotide polymorphisms with support vector regression in continuous phenotypes
Author:
Shahidain, Seif
Document Type:
Thesis
Department:
Department of Mathematical Sciences
Degree:
Master of Science
Major:
Computational Biology
Advisory Committee:
Roshan, Usman W.
Wei, Zhi
Dhar, Sunil Kumar
Thesis Date:
2011, May
Keywords:
Support vector machines
Single nucleotide polymorphisms
Continuous phenotypes
Availability:
Unrestricted
Abstract:

Support vector machines (SVM) have been used to improve the ranking of single nucleotide polymorphisms (SNPs) over traditional chi-square tests in disease case studies [2]. In this investigation, ranking SNPs with support vector regression (SVR) was compared to the Wald test in predicting continuous phenotypes. SVR-ranked SNPs consistently outperformed the Wald test-ranked SNPs to provide a more accurate prediction of the phenotype with fewer SNPs across several methods of prediction.

Complete Thesis:
njit-etd2011-082 (59 pages ~ 6,976 KB pdf)
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Created August 18, 2011
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