| Title: | RNA genome annotation with a focus on T. brucei |
| Author: | |
| Document Type: | Thesis |
| Department: | Department of Computer Science |
| Degree: | Master of Science |
| Major: | Computational Biology |
| Advisory Committee: |
Wang, Jason T. L.
Sohn, Andrew
Theodoratos, Dimitri
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| Thesis Date: | 2008, January |
| Keywords: |
RNA genome
T. brucei
African sleeping sickness
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| Availability: | Unrestricted |
| Abstract: |
The goal of this project is to identify untranslated regions (UTRs) and UTR-indicating patterns in the genome of T. brucei. T. brucei is an interesting organism, and as the cause of African sleeping sickness -- which infects 300,000-500,000 people and a significant number of cattle annually -- is currently the subject of considerable research. Using existing algorithms, several patterns have been found that may lead to more complete UTR annotations in the T. brucei genome. The most encouraging sequence is the 11-base sequence GAGGGIICG]TGGGG, which appears in five hypothetical genes near the tail. Discovery of several such sequences could guide laboratory experimentation toward more useful results and a better allocation of time and resources. |
| Complete Thesis: |
njit-etd2008-008
(47 pages ~ 2,420 KB pdf)
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Created September 15, 2008
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