SNP auto-calling using artificial neural networks
Department of Computer Science
Master of Science
Shih, Frank Y.
DNA microarray analysis
Artificial neural networks
In recent years feedforward artificial neural networks (ANN) and their training algorithms have become an effective methodology for the construction of nonlinear systems that solve the statistical problem of classification. The ability of ANNs to solve this problem is highly germane to making progress in the refinement of DNA microarray analysis and techniques regarding this issue. This study attempts to deal with the classification of microarray data and the comparison and validation of simple feedforward ANNs in partitioning high dimensional data. In doing this the efficacy of using ANNs as a genotyping tool will be proven. Furthermore, it has been determined through extensive testing that the classification abilities of simple feedforward ANNs are at least comparable with that of SVMs.
njit-etd2005-119 (68 pages ~ 4,285 KB pdf)
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Created September 8, 2008