| Title: | Wet-spinning and thermal analysis of collagen fibers incorporating hydroxyapatite in mixed and coated form |
| Author: | |
| Document Type: | Thesis |
| Department: | Department of Biomedical Engineering |
| Degree: | Master of Science |
| Major: | Biomedical Engineering |
| Advisory Committee: |
Jaffe, Michael
Collins, George
Arinzeh, Treena Livingston
|
| Thesis Date: | 2005, August |
| Keywords: |
Collagen fibers
Wet-spinning
Thermal analysis
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| Availability: | Unrestricted |
| Abstract: |
The composition of natural bone comprises of collagen (Cg) as organic
phase which acts as a matrix and inorganic calcium phosphate, particularly
hydroxyapatite (HA), which is used as reinforcement. This study involved
the wet-spinning of collagen fibers incorporating HA in mixed and coated
form. The weight percent ratio of collagen and HA in the composite fibers
was 95 to 5 respectively. HA coating on pure collagen fibers was achieved
by immersing them in HA solution formed by mixing HA in water. With Thermomechanical
analysis, the highest breaking point temperature was obtained for the
composite fibers and the least with pure collagen fibers. The HA coated
collagen fibers had breaking point temperature between these two fibers.
However, tensile modulus was seen to be highest for pure collagen fibers
and the least for the composite fibers. Thermogravimetric analysis was
performed on the fibers to monitor the weight reduction with respect to
temperature. The highest reduction was obtained with pure collagen fibers
and the least with the composite fibers. HA coating on the collagen fibers
was evident from X-ray diffraction analysis and EP-DIC images. This study
showed a new method of coating collagen fibers with HA crystals. CgIHA
composite fibers were spun for the first time using Wet-Spinning apparatus.
With thermal analysis it was evident that HA has low load bearing property
and high melting point temperature. Osteoconduction and Osteoinduction
are needed to be done on these fibers as a future work.
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| Complete Thesis: |
njit-etd2005-114
(63 pages ~ 4,454 KB pdf)
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Created February 4, 2008
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