NJIT eTD::njit-etd1992-021::Agostinho, Maria L.::"Mathematical model and simulation of the progression of cutaneous T-cell lymphoma"

A simple mathematical model and simulation of the progression of cancer with particular emphasis on Cutaneous T Cell Lymphoma was investigated. The mathematical model consists of a set of differential equations that first satisfies the homeostasis levels of the different components present and second predicts the dynamics during a diseased or unhealthy condition. The simulation was done using a FORTRAN program for integrating the differential equations.

Simulation of the immune system is important in evaluating the usefulness of particular sorts of biologically targeted therapies and in selecting the most promising treatment strategies for clinical trials. In particular, the effects of leukapheresis and photopheresis in the treatment of CTCL was investigated using the model and available data. Simulation is also important for testing the effectiveness of new drugs on the system.

Title:	Mathematical model and simulation of the progression of cutaneous T-cell lymphoma
Author:	Agostinho, Maria L.
Document Type:	Thesis
Department:	Biomedical Engineering Committee
Degree:	Master of Science
Major:	Biomedical Engineering
Advisory Committee:	Sofer, Samir S. Kristol, David S. Ritter, Arthur B.
Thesis Date:	1992, October
Keywords:	T cells. Lymphomas--Growth--Mathematical models.
Availability:	Unrestricted
Abstract:	A simple mathematical model and simulation of the progression of cancer with particular emphasis on Cutaneous T Cell Lymphoma was investigated. The mathematical model consists of a set of differential equations that first satisfies the homeostasis levels of the different components present and second predicts the dynamics during a diseased or unhealthy condition. The simulation was done using a FORTRAN program for integrating the differential equations. Simulation of the immune system is important in evaluating the usefulness of particular sorts of biologically targeted therapies and in selecting the most promising treatment strategies for clinical trials. In particular, the effects of leukapheresis and photopheresis in the treatment of CTCL was investigated using the model and available data. Simulation is also important for testing the effectiveness of new drugs on the system.
Complete Thesis:	njit-etd1992-021 (66 pages ~ 2,770 KB pdf)
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